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Tier 2 and 3 medicine supply notifications

Estradiol, Estriol, Oral Oxycodone, Clarithromycin, Alfuzosin 10mg modified release tablets

April 11th 2023

Tagged: supply shortages

By Ailsa Colquhoun

Four Tier 2 and one tier 3 medicine supply notifications have been issued for the following items:

Tier 2

  • Estradiol (Estradot) 75micrograms/24hours transdermal patches
  • Estriol (Imvaggis) 0.03mg pessary
  • Clarithromycin 125mg/5ml and 250mg/5ml oral suspensions
  • Alfuzosin 10mg modified release tablets

Tier 3

  • Oxycodone Hydrochloride 5mg/5ml Oral Solution
MedicineOut of stockAlternatives
Estradiol (Estradot) 75micrograms/24hours transdermal patchesUntil early May 2023


Evorel 75micrograms/24hours transdermal patches

See MSN for details.


Estriol (Imvaggis) 0.03mg pessaryUntil mid-late May 2023Alternative estriol vaginal products

Estradiol 10mcg vaginal tablets

Alfuzosin 10mg modified release tabletsUntil w/c 15 May 2023


Alternative alpha-adrenoceptor blockers are available

See MSN for details


Oxycodone Hydrochloride 5mg/5ml Oral SolutionUntil end of June 2023Oxycodone 5mg and 10mg immediate release capsules

Alternative liquid opioid formulations

Specials oxycodone 5mg/5ml oral suspension have been sourced.

See MSN for details

Clarithromycin 125mg/5ml oral suspension

Clarithromycin 250mg/5ml oral suspension

125mg/5ml oral suspension – until w/c 10 April 2023

250mg/5ml oral suspension – limited supply until w/c 10 April 2023

Alternative clarithromycin preparations

Serious Shortage Protocol’s (SSP) were issued on 06/04/2023


Up-to-date information about medicine supply issues is available via the online Medicines Supply Tool (SPS registration required)